Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats
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چکیده
منابع مشابه
Modulation of cutaneous aging with calorie restriction in Fischer 344 rats: a histological study.
OBJECTIVE To examine whether histological changes in skin owing to intrinsic aging in a laboratory rodent model are modulated by caloric restriction (CR). METHODS The abdominal skin from colony-raised ad libitum-fed Fischer 344 rats and age-matched rats subjected to CR was studied in the light microscope using histological morphometric methods. Animals 4, 12, and 24 months or older were used ...
متن کاملAging increases upper airway collapsibility in Fischer 344 rats.
The upper airway muscles play an important role in maintaining upper airway collapsibility, and the incidence of sleep-disordered breathing increases with age. We hypothesize that the increase in airway collapsibility with increasing age can be linked to changes in upper airway muscle mechanics and structure. Eight young (Y: 6 mo) and eight old (O: 30 mo) Fischer 344 rats were anesthetized and ...
متن کاملPsychomotor and spatial memory performance in aging male Fischer 344 rats.
Psychomotor and spatial memory performance were examined in male Fischer 344 rats that were 6, 12, 15, 18, and 22 months of age, to assess these parameters as a function of age and to determine at what age these behaviors begin to deteriorate. Complex motor behaviors, as measured by rod walk, wire suspension, plank walk, inclined screen, and accelerating rotarod performance, declined steadily w...
متن کاملAge-Related Differences in Hearing Function and Cochlear Morphology between Male and Female Fischer 344 Rats
Fischer 344 (F344) rats represent a strain that is frequently used as a model for fast aging. In this study, we systematically compare the hearing function during aging in male and female F344 rats, by recording auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAEs). In addition to this, the functional parameters are correlated with the cochlear histology. The...
متن کاملBrief dietary restriction increases skeletal muscle glucose transport in old Fischer 344 rats.
The primary purpose of this study was to determine the impact of brief dietary restriction (DR; 5 or 20 days) on skeletal muscle glucose transport activity (GTA) of 24-month-old female Fischer 344 rats. Basal GTA of isolated epitrochlearis muscles was unaffected by DR. Insulin-stimulated GTA was significantly increased by DR only at 20 days (51%). We also assessed the influence of DR on energy ...
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ژورنال
عنوان ژورنال: GeroScience
سال: 2019
ISSN: 2509-2715,2509-2723
DOI: 10.1007/s11357-019-00129-4